The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 24, 2017

Filed:

Mar. 14, 2014
Applicants:

The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);

Sri International, Menlo Park, CA (US);

Inventors:

Mary Jean Tanga, Los Altos, CA (US);

Laura Ellen Downs Beaulieu, El Cerrito, CA (US);

Anton Wyss-Coray, Palo Alto, CA (US);

Carol Green, Portola Valley, CA (US);

Hui Zhang, Sunnyvale, CA (US);

Jian Luo, Palo Alto, CA (US);

Assignee:

Other;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 211/26 (2006.01); A61K 31/4465 (2006.01); A61K 31/452 (2006.01);
U.S. Cl.
CPC ...
C07D 211/26 (2013.01); A61K 31/4465 (2013.01); A61K 31/452 (2013.01);
Abstract

Compositions and methods for treatment and prevention of disorders and conditions characterized by reduced TGF-B signaling are described. In particular, the compositions and methods are useful for reducing or eliminating the pathologies associated with Alzheimer's disease. The compositions include urea derivatives containing a piperidine, piperidinium, or a piperidin-4-yl methyl; cycloalkyl, aryl, and fluorobenzyl moieties.


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