The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 24, 2017
Filed:
Nov. 20, 2013
Brigham and Women's Hospital, Inc., Boston, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Vilnius University, Vilnius, LT;
Joseph Italiano, Chestnut Hill, MA (US);
Linas Mazutis, Boston, MA (US);
Jonathan N. Thon, Cambridge, MA (US);
David A. Weitz, Boston, MA (US);
Joseph Italiano, Chestnut Hill, MA (US);
Linas Mazutis, Boston, MA (US);
Jonathan N. Thon, Cambridge, MA (US);
David A. Weitz, Boston, MA (US);
Brigham and Women's Hospital, Inc., Boston, MA (US);
Abstract
A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.