The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 24, 2017

Filed:

Mar. 18, 2014
Applicant:

Zimmer Trabecular Metal Technology, Inc., Parsippany, NJ (US);

Inventors:

Zou Xuenong, Aarhus N., DK;

Haisheng Li, Viby J., DK;

Cody Bunger, Auning, DK;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61L 27/56 (2006.01); A61L 27/38 (2006.01); A61L 27/06 (2006.01); A61L 27/08 (2006.01); A61F 2/28 (2006.01); A61F 2/34 (2006.01); C12N 5/00 (2006.01); C12N 5/0775 (2010.01); A61L 27/00 (2006.01); A61L 27/20 (2006.01); A61L 27/22 (2006.01); A61L 27/54 (2006.01); A61F 2/30 (2006.01); A61F 2/32 (2006.01); A61F 2/36 (2006.01); A61F 2/38 (2006.01); A61F 2/44 (2006.01); A61F 2/46 (2006.01); A61F 2/00 (2006.01); A61L 27/36 (2006.01);
U.S. Cl.
CPC ...
A61L 27/56 (2013.01); A61F 2/28 (2013.01); A61F 2/34 (2013.01); A61L 27/00 (2013.01); A61L 27/20 (2013.01); A61L 27/22 (2013.01); A61L 27/38 (2013.01); A61L 27/54 (2013.01); C12N 5/0068 (2013.01); C12N 5/0662 (2013.01); A61F 2/3094 (2013.01); A61F 2/30767 (2013.01); A61F 2/32 (2013.01); A61F 2/36 (2013.01); A61F 2/38 (2013.01); A61F 2/44 (2013.01); A61F 2/4644 (2013.01); A61F 2002/0086 (2013.01); A61F 2002/2817 (2013.01); A61F 2002/2867 (2013.01); A61F 2002/3093 (2013.01); A61F 2002/30199 (2013.01); A61F 2002/30225 (2013.01); A61F 2002/30677 (2013.01); A61F 2002/30678 (2013.01); A61F 2002/30981 (2013.01); A61F 2002/4648 (2013.01); A61F 2230/0063 (2013.01); A61F 2230/0069 (2013.01); A61F 2310/00161 (2013.01); A61F 2310/00293 (2013.01); A61F 2310/00341 (2013.01); A61F 2310/00491 (2013.01); A61F 2310/00544 (2013.01); A61F 2310/00976 (2013.01); A61F 2310/00982 (2013.01); A61L 27/3608 (2013.01); A61L 2300/222 (2013.01); A61L 2300/252 (2013.01); A61L 2300/606 (2013.01); A61L 2300/64 (2013.01); A61L 2400/18 (2013.01); A61L 2430/00 (2013.01);
Abstract

Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or in combination with recombinant growth factors or transfected osteogenic genes. The scaffold-implant may be machined into a custom-shaped three-dimensional cell culture system for support of cell growth, reservoir for peptides, recombinant growth factors, cytokines and antineoplastic drugs in the presence of a hyaluronan and/or dexamethasone alone or in combination with growth factors or transfected osteogenic genes, to be assembled ex vivo in a tissue incubator for implantation into bone tissue.


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