The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2017
Filed:
Feb. 27, 2015
Applicants:
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
University of Newcastle Upon Tyne, Newcastle Upon Tyne, GB;
Inventors:
Susanna Falcon, Newbury, GB;
Philip Reaper, Shillingford, GB;
John Pollard, Abingdon, GB;
Nicola Curtin, Newcastle upon Tyne, GB;
Fiona Middleton, South Gosforth, GB;
Tao Chen, SuZhou, CN;
Assignees:
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
University of Newcastle Upon Tyne, Newcastle Upon Tyne, GB;
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2006.01); G01N 33/573 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6875 (2013.01); G01N 33/5047 (2013.01); G01N 33/573 (2013.01); G01N 33/68 (2013.01); G01N 2333/4703 (2013.01); G01N 2333/912 (2013.01); G01N 2440/14 (2013.01);
Abstract
The present relates to methods for detecting DNA damage in subjects treated with an ATR inhibitor. More specifically, this invention relates to a method for measuring changes in levels of γH2AX and/or pChk1in, e.g., surrogate tissue cells, following ex vivo stimulation with a DNA damaging agent.