The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 17, 2017

Filed:

Sep. 12, 2013
Applicant:

The University of Queensland, St Lucia, AU;

Inventors:

Kirill Alexandrov, St Lucia, AU;

Viktor Stein, St Lucia, AU;

Matt Trau, St Lucia, AU;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/542 (2006.01); C12Q 1/37 (2006.01); G01N 33/543 (2006.01); C12N 9/50 (2006.01); C12N 15/62 (2006.01); C07K 16/30 (2006.01); C07K 16/36 (2006.01); G01N 33/573 (2006.01); G01N 33/532 (2006.01);
U.S. Cl.
CPC ...
G01N 33/542 (2013.01); C07K 16/3069 (2013.01); C07K 16/36 (2013.01); C12N 9/503 (2013.01); C12N 9/506 (2013.01); C12N 15/62 (2013.01); C12Q 1/37 (2013.01); G01N 33/532 (2013.01); G01N 33/54366 (2013.01); G01N 33/573 (2013.01); C07K 2317/22 (2013.01); C07K 2317/569 (2013.01); C07K 2319/21 (2013.01); C07K 2319/50 (2013.01); C07K 2319/70 (2013.01); C12N 2770/24022 (2013.01); C12N 2770/34022 (2013.01); G01N 2333/005 (2013.01); G01N 2333/18 (2013.01); G01N 2333/96463 (2013.01);
Abstract

A biosensor molecule comprises: a protease amino acid sequence; at least one sensor comprising at least one sensor amino acid sequence which is responsive to at least one target molecule; and an inhibitor of the protease activity of said protease amino acid sequence; wherein the biosensor is switchable from a protease active to a protease inactive state, or from a protease inactive to a protease active state when said sensor responds to said target molecule. The biosensor protease may be a protease of a virus such as a Potyvirus or a Flavivirus wherein the inhibitor is an autoinhibitory peptide derived from the virus. The biosensor may respond to the target molecule allosterically or may be cleaved by a target protease molecule.


Find Patent Forward Citations

Loading…