The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2017
Filed:
Mar. 13, 2014
Marc P. Raphael, Washington, DC (US);
Joseph A. Christodoulides, Alexandria, VA (US);
Jeff M. Byers, Fairfax Station, VA (US);
James B. Delehanty, Washington, DC (US);
Marc P. Raphael, Washington, DC (US);
Joseph A. Christodoulides, Alexandria, VA (US);
Jeff M. Byers, Fairfax Station, VA (US);
James B. Delehanty, Washington, DC (US);
The United States of America as represented by the Secretary of the Navy, Washington, DC (US);
Abstract
A label-free method for the spatio-temporal mapping of protein secretions from individual cells in real time by using a chip for localized surface plasmon resonance (LSPR) imaging. The chip is a glass coverslip compatible for use in a standard microscope having at least one array of functionalized plasmonic nanostructures patterned onto it. After placing a cell on the chip, the secretions from the cell are spatially and temporally mapped using LSPR imaging. Transmitted light imaging and/or fluorescence imaging may be done simultaneously with the LSPR imaging.