The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2017
Filed:
Jul. 31, 2015
Applicant:
Gradalis, Inc., Dallas, TX (US);
Inventors:
John J. Nemunaitis, Cedar Hill, TX (US);
Neil Senzer, Dallas, TX (US);
Phillip B. Maples, Pilot Point, TX (US);
Donald Rao, Dallas, TX (US);
Assignee:
GRADALIS, INC., Dallas, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12N 15/85 (2006.01); A61K 39/00 (2006.01); A61K 38/21 (2006.01); A61K 35/13 (2015.01); A61K 31/7105 (2006.01); A61K 31/7088 (2006.01); A61K 48/00 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
C12N 15/85 (2013.01); A61K 31/7088 (2013.01); A61K 31/7105 (2013.01); A61K 35/13 (2013.01); A61K 38/217 (2013.01); A61K 39/0011 (2013.01);
Abstract
Compositions and methods for cancer treatment are disclosed herein. More specifically, the present invention describes an autologous cancer vaccine genetically modified for Furin knockdown and GM-CSF expression. The vaccine described herein attenuates the immunosuppressive activity of TGF-β through the use of bi-functional shRNAs to knock down the expression of furin in cancer cells, and to segment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene.