The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2017
Filed:
Jul. 15, 2016
Yuzhuo Wang, Vancouver, CA;
Hui Xue, Vancouver, CA;
Sze Ue Luk, Vancouver, CA;
Peter Wilhelm Gout, Vancouver, CA;
Martin E. Gleave, Vancouver, CA;
Colin C. Collins, Vancouver, CA;
Yuzhuo Wang, Vancouver, CA;
Hui Xue, Vancouver, CA;
Sze Ue Luk, Vancouver, CA;
Peter Wilhelm Gout, Vancouver, CA;
Martin E. Gleave, Vancouver, CA;
Colin C. Collins, Vancouver, CA;
Other;
Abstract
Provided herein are compositions, method and uses for modulating IAP activity or for the treatment of cancer. The compositions comprise dual-targeting antisense oligonucleotides (dASO) for administration to a cancer cell, wherein the cancer cell may be characterized by elevated expression of one of more of BIRC6, cIAP1 or survivin. The cancer may be selected from one or more of: prostate cancer; childhood de novo acute myeloid leukemia; colorectal cancer; neuroblastoma; melanoma; and non-small cell lung cancer. The prostate cancer may be castration-resistant prostate cancer (CRPC).