The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9790185 B1

PDF
Full Text
Expired
Date of Patent:
Oct. 17, 2017

Filed:

Jul. 06, 2015
Applicant:

Shilpa Medicare Limited, Raichur,karnataka, IN;

Inventors:

Sriram Rampalli, Vizianagaram, IN;

Lav Kumar Upalla, Vizianagaram, IN;

Krishna Kumar Ramachandrula, Vizianagaram, IN;

Prashant Purohit, Raichur, IN;

Chaturvedi Akshay Kant, Raichur, IN;

Assignee:

SHILPA MEDICARE LIMITED, Karnataka, unknown;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 213/81 (2006.01);
U.S. Cl.
CPC ...
C07D 213/81 (2013.01);
Abstract

The present invention relates to a process for the preparation of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide or Regorafenib (I). The present invention further relates to a process for the purification of 4-[4-({[4-chloro-3-(trifluoromethyl) phenyl] carbamoyl} amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide or Regorafenib (I) to provide highly pure material. The present invention further relates to a process for the preparation stable crystalline material of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methyl pyridine-2-carboxamide or Regorafenib (I) useful in the preparation of pharmaceutical compositions for the treatment of cancer.


Find Patent Forward Citations

Rampalli, Sriram. (2017). Process for the preparation of regorafenib and its crystalline forms (U.S. Patent No. 9790185). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9790185

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