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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9790174 B1

PDFFull Text
Date of Patent:
Oct. 17, 2017

Filed:

Sep. 09, 2016

Kinase inhibitors

Applicants:

Respivert Limited, Buckinghamshire, GB;

Topivert Pharma Limited, London, GB;

Inventor:

Stephen Malcolm Thom, Nottingham, GB;

Assignees:

Respivert Limited, Buckinghamsire, GB;

Topivert Pharma Limited, London, GB;

Attorney:

Knobbe, Martens Olson & Bear, LLP

Primary Examiner:

Alexander R Pagano

Assistant Examiner:

Ebenezer O Sackey

Int. Cl.
CPC ...
C07C 317/48 (2006.01); C07C 317/28 (2006.01); C07D 233/90 (2006.01); A61K 31/5377 (2006.01); C07D 239/47 (2006.01); C07D 211/86 (2006.01); A61K 31/44 (2006.01); A61K 31/506 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); A61K 31/444 (2006.01); A61K 31/4427 (2006.01); A61K 31/505 (2006.01); A61K 31/541 (2006.01); A61K 31/551 (2006.01); A61K 31/553 (2006.01); C07C 311/08 (2006.01); C07D 403/12 (2006.01); C07D 213/74 (2006.01); C07D 401/12 (2006.01); C07D 413/12 (2006.01);
U.S. Cl.
CPC ...
C07C 317/48 (2013.01); A61K 31/44 (2013.01); A61K 31/444 (2013.01); A61K 31/4427 (2013.01); A61K 31/505 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/541 (2013.01); A61K 31/551 (2013.01); A61K 31/553 (2013.01); C07C 311/08 (2013.01); C07C 317/28 (2013.01); C07D 211/86 (2013.01); C07D 213/74 (2013.01); C07D 233/90 (2013.01); C07D 239/47 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 413/12 (2013.01);
Abstract

There are provided compounds of formula IIb, wherein LGrepresents imidazolyl, chloro or aryloxy, which compounds are useful in the preparation of compounds that have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

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