The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 17, 2017

Filed:

Feb. 17, 2017
Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Andrew Harvey, Thebarton, AU;

Thomas Avery, Thebarton, AU;

Dharam Paul, Thebarton, AU;

Justin Ripper, Thebarton, AU;

Belinda Huff, Thebarton, AU;

Rajinder Singh, Thebarton, AU;

Laurent Schaeffer, Illkirch, FR;

Christophe Joseph, Illkirch, FR;

Christophe Morice, Illkirch, FR;

Bruno Giethlen, Illkirch, FR;

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 261/14 (2006.01); C07C 217/82 (2006.01); C07C 311/30 (2006.01); C07C 311/37 (2006.01); C07D 213/74 (2006.01); C07D 295/135 (2006.01);
U.S. Cl.
CPC ...
C07C 311/37 (2013.01); C07C 217/82 (2013.01); C07C 311/30 (2013.01); C07D 213/74 (2013.01); C07D 261/14 (2013.01); C07D 295/135 (2013.01);
Abstract

The present invention relates to chemical compounds of formula (I), with the substituents as described in the specification, useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (α7 nAChR). The invention also relates to the use of these compounds in the treatment or prevention of a broad range of diseases in which the positive modulation of α7 nAChR is advantageous, including neurodegenerative and neuropsychiatric diseases and also neuropathic pain and inflammatory diseases.


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