The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 17, 2017

Filed:

Oct. 02, 2013
Applicant:

Dsm Ip Assets B.v., Heerlen, NL;

Inventors:

Jens Christoph Thies, Echt, NL;

George Mihov, Echt, NL;

Guy Draaisma, Echt, NL;

Assignee:

DSM IP ASSETS BV, Heerlen, NL;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/34 (2006.01); A61K 47/30 (2006.01); A61K 47/42 (2006.01); C08G 69/44 (2006.01); C08L 77/12 (2006.01); A61K 38/44 (2006.01);
U.S. Cl.
CPC ...
A61K 47/34 (2013.01); A61K 38/44 (2013.01); C08G 69/44 (2013.01); C08L 77/12 (2013.01); C12Y 111/01007 (2013.01);
Abstract

Drug delivery compositions are provided having proteins and biodegradable polymers that may be used for controlled and long term release of proteins into a biological environment. According to some embodiments, the drug delivery composition may be provided with at least a protein and a biodegradable polymer possessing at least two different functional groups selected from the group of chosen among carboxyl, ester, amine, amide, thiol, thioester or hydroxyl groups pendant to the main polymer chain whereby the composition absorbs between 5-10% w/w water when exposed to physiological conditions for at least 20 days. A drug delivery system for controlled protein release which includes the drug delivery composition is also provided whereby the drug delivery system may be in the form of microparticles, films, coatings, fibers, pellets, cylinders, discs, implants, microcapsules, microspheres, nanospheres, wafers, micelles, liposomes or woven or non-woven fabrics.


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