The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2017
Filed:
Sep. 04, 2014
Applicant:
Board of Regents of the University of Texas System, Austin, TX (US);
Inventors:
Joseph M. Ready, Carrollton, TX (US);
Deepak Nijhawan, Dallas, TX (US);
Stephen S. Gonzales, Frisco, TX (US);
Pano Theodoropoulos, Dallas, TX (US);
Assignee:
Board of Regents of the University of Texas System, Austin, TX (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/428 (2006.01); A61K 31/426 (2006.01); C07C 235/88 (2006.01); C07D 333/70 (2006.01); C07D 409/12 (2006.01); C07D 417/12 (2006.01); C07D 513/04 (2006.01); C12N 9/99 (2006.01); A61K 31/381 (2006.01); C07D 405/14 (2006.01); C07D 213/75 (2006.01); C07D 215/48 (2006.01); C07D 217/02 (2006.01); C07D 405/12 (2006.01); C07D 409/14 (2006.01); C07D 239/90 (2006.01); C07D 417/14 (2006.01); C07D 209/08 (2006.01); C07D 277/82 (2006.01); C07D 209/44 (2006.01); C07C 271/44 (2006.01); C07C 271/46 (2006.01); C07C 271/48 (2006.01); C07C 275/24 (2006.01); C07C 275/30 (2006.01); C07C 275/54 (2006.01); C07C 233/56 (2006.01); C07C 233/73 (2006.01); C07C 235/38 (2006.01); C07C 235/56 (2006.01); C07C 235/66 (2006.01); C07C 235/70 (2006.01); C07C 237/08 (2006.01);
U.S. Cl.
CPC ...
A61K 31/426 (2013.01); A61K 31/381 (2013.01); A61K 31/428 (2013.01); C07C 233/56 (2013.01); C07C 233/73 (2013.01); C07C 235/38 (2013.01); C07C 235/56 (2013.01); C07C 235/66 (2013.01); C07C 235/70 (2013.01); C07C 235/88 (2013.01); C07C 237/08 (2013.01); C07C 271/44 (2013.01); C07C 271/46 (2013.01); C07C 271/48 (2013.01); C07C 275/24 (2013.01); C07C 275/30 (2013.01); C07C 275/54 (2013.01); C07D 209/08 (2013.01); C07D 209/44 (2013.01); C07D 213/75 (2013.01); C07D 215/48 (2013.01); C07D 217/02 (2013.01); C07D 239/90 (2013.01); C07D 277/82 (2013.01); C07D 333/70 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 513/04 (2013.01); C12N 9/99 (2013.01); C07C 2101/02 (2013.01); C07C 2101/04 (2013.01); C07C 2101/08 (2013.01); C07C 2101/14 (2013.01); C07C 2101/18 (2013.01); C07C 2103/26 (2013.01);
Abstract
Provided herein are methods and compositions for selective and targeted cancer therapy, in particular certain benzothiophenes, benzothiazoles, oxalamides, N-acyl ureas and chromones, and their use in selectively treating certain adenocarcinomas. In some embodiments, the selective toxicity of the compounds may be mediated through SCD1 and/or CYP450 such as CYP4F11.