The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2017
Filed:
Mar. 14, 2013
Applicant:
City of Hope, Duarte, CA (US);
Inventors:
Hsun Ku, Arcadia, CA (US);
David Tirrell, Pasadena, CA (US);
Assignees:
CITY OF HOPE, Duarte, CA (US);
CALIFORNIA INSTITUTE OF TECHNOLOGY, Pasadena, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/02 (2006.01); C12N 5/071 (2010.01); A61K 35/39 (2015.01); C12Q 1/68 (2006.01); G01N 33/569 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0678 (2013.01); A61K 35/39 (2013.01); C12Q 1/6881 (2013.01); G01N 33/56966 (2013.01); C12N 2501/16 (2013.01); C12N 2501/335 (2013.01); C12N 2501/415 (2013.01); C12N 2501/58 (2013.01); C12N 2533/52 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/70596 (2013.01);
Abstract
In some embodiments, methods for improving the survival of pancreatic β-cell progenitors in culture are provided. Such methods may include contacting a population of pancreatic progenitor cells with an amino acid (aa) sequence comprising IKVAV (SEQ ID NO:1). In other embodiments, methods for (i) verifying the establishment of a population of pancreatic progenitor or stem cells and (ii) methods for generating or establishing a population of pancreatic endocrine progenitor cells in vitro are provided.