The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2017
Filed:
Aug. 02, 2016
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);
Mark Connors, Bethesda, MD (US);
Jinghe Huang, Bethesda, MD (US);
Leo B. Laub, Richmond, VA (US);
Peter Kwong, Washington, DC (US);
Gary Nabel, Cambridge, MA (US);
John R. Mascola, Rockville, MD (US);
Baoshan Zhang, Bethesda, MD (US);
Rebecca S. Rudicell, Silver Springs, MD (US);
Ivelin Georgiev, Gaithersburg, MD (US);
Yongping Yang, Potomac, MD (US);
Jiang Zhu, Ashburn, VA (US);
Gilad Ofek, Washington, DC (US);
Abstract
Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of HIV-1 in a biological sample, or detecting an HIV-1 infection or diagnosing AIDS in a subject. In additional, the broad neutralization breadth of the disclosed antibodies makes them ideal for treating a subject with an HIV infection. Thus, disclosed are methods of treating and/or preventing HIV infection.