The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2017
Filed:
Feb. 08, 2016
Applicant:
New York University, New York, NY (US);
Inventors:
Paramjit S. Arora, Cold Spring Harbor, NY (US);
Brooke Bullock Lao, Leesville, SC (US);
Assignee:
New York University, New York, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/496 (2006.01); C07D 403/06 (2006.01); C07D 403/14 (2006.01); C07D 241/08 (2006.01); C12N 15/63 (2006.01);
U.S. Cl.
CPC ...
C07D 403/06 (2013.01); A61K 31/496 (2013.01); C07D 241/08 (2013.01); C07D 403/14 (2013.01); C12N 15/63 (2013.01);
Abstract
The present invention relates to oligooxopiperazines that mimic helix αB of the C-terminal transactivation domain of HIF-1α. Also disclosed are pharmaceutical compositions containing these oligooxopiperazines and methods of using these oligooxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1α with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).