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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9783498 B1

PDFFull Text
Expired
Date of Patent:
Oct. 10, 2017

Filed:

Jan. 17, 2014

Process for preparing the anti-tumor agent 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-n-methyl-1-naphthamide and its crystalline

Applicant:

Advenchen Pharmaceuticals, Llc, Moorpark, CA (US);

Inventor:

Guoqing Paul Chen, Westlake Village, CA (US);

Assignee:

Advenchen Pharmaceuticals, LLC, Moorpark, CA (US);

Attorney:
Primary Examiner:

Patricia L Morris

Int. Cl.
CPC ...
C07D 215/233 (2006.01); C07D 215/22 (2006.01); C07C 271/24 (2006.01); C07C 231/02 (2006.01); C07C 269/00 (2006.01); C07C 269/06 (2006.01); C07C 303/26 (2006.01); C07D 215/20 (2006.01); C07C 309/66 (2006.01);
U.S. Cl.
CPC ...
C07D 215/22 (2013.01); C07C 231/02 (2013.01); C07C 269/00 (2013.01); C07C 269/06 (2013.01); C07C 271/24 (2013.01); C07C 303/26 (2013.01); C07C 309/66 (2013.01); C07D 215/20 (2013.01); C07D 215/233 (2013.01); C07B 2200/13 (2013.01); C07C 2101/02 (2013.01);
Abstract

The present invention relates a new process to synthesize 6-(7-((1-aminocyclo-propyl)-methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide (AL3810) by deprotection of substituted benzyl 1-((6-methoxy-4-(5-(methylcarbamoyl)naphthalen-2-yloxy)quinolin-7-yloxy)-methyl)cyc-lopropylcarbamate (Formula I) under a diluted or weak acidic condition. A stable crystalline form of 6-(7-((1-aminocyclo-propyl)-methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide has also been prepared.

Find Patent Forward Citations

Chen, Guoqing. (2017). Process for preparing the anti-tumor agent 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-n-methyl-1-naphthamide and its crystalline (U.S. Patent No. 9783498). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9783498

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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