The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2017
Filed:
Jan. 17, 2014
Applicant:
Advenchen Pharmaceuticals, Llc, Moorpark, CA (US);
Inventor:
Guoqing Paul Chen, Westlake Village, CA (US);
Assignee:
Advenchen Pharmaceuticals, LLC, Moorpark, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 215/233 (2006.01); C07D 215/22 (2006.01); C07C 271/24 (2006.01); C07C 231/02 (2006.01); C07C 269/00 (2006.01); C07C 269/06 (2006.01); C07C 303/26 (2006.01); C07D 215/20 (2006.01); C07C 309/66 (2006.01);
U.S. Cl.
CPC ...
C07D 215/22 (2013.01); C07C 231/02 (2013.01); C07C 269/00 (2013.01); C07C 269/06 (2013.01); C07C 271/24 (2013.01); C07C 303/26 (2013.01); C07C 309/66 (2013.01); C07D 215/20 (2013.01); C07D 215/233 (2013.01); C07B 2200/13 (2013.01); C07C 2101/02 (2013.01);
Abstract
The present invention relates a new process to synthesize 6-(7-((1-aminocyclo-propyl)-methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide (AL3810) by deprotection of substituted benzyl 1-((6-methoxy-4-(5-(methylcarbamoyl)naphthalen-2-yloxy)quinolin-7-yloxy)-methyl)cyc-lopropylcarbamate (Formula I) under a diluted or weak acidic condition. A stable crystalline form of 6-(7-((1-aminocyclo-propyl)-methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide has also been prepared.