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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9777060 B1

PDFFull Text
Date of Patent:
Oct. 03, 2017

Filed:

May. 18, 2015

Antibody binding specifically to human and mouse l1cam protein, and use therefor

Applicants:

Kangwon National University University-industry Cooperation Foundation, Chuncheon-si, KR;

Korea Research Institute of Bioscience and Biotechnology, Daejeon, KR;

Inventors:

Hyo Jeong Hong, Chuncheon-si, KR;

In Soo Park, Goyang-si, KR;

Seul Ki Cho, Busan, KR;

Mun Sik Jeong, Chungcheongbuk-do, KR;

Singh Rohit, Chuncheon-si, KR;

Assignees:

KANGWON NATIONAL UNIVERSITY University-Industry Cooperation Foundation, Chuncheon-si, KR;

Korea Research Insititute of Bioscience and Biotechnology, Daejeon, KR;

Attorneys:

Lathrop Gage LLP

Andrew T. Wilkins

Brian C. Trinque

Primary Examiner:

Maher Haddad

Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 39/44 (2006.01); G01N 33/53 (2006.01); C07K 16/00 (2006.01); C07K 16/46 (2006.01); C07K 16/28 (2006.01); C07H 21/04 (2006.01); C12P 21/06 (2006.01); C12N 15/87 (2006.01); C12N 1/20 (2006.01); C12N 15/74 (2006.01); A61K 47/48 (2006.01); G01N 33/574 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2803 (2013.01); A61K 47/48569 (2013.01); G01N 33/57492 (2013.01); A61K 2039/505 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/92 (2013.01); G01N 2333/70503 (2013.01); G01N 2333/70596 (2013.01);
Abstract

The present invention relates to a novel antibody specifically binding to human and mouse L1CAM, and more particularly, to an antibody binding to both human and mouse L1CAM with high affinity, which is prepared by modifying a sequence of an L1 cell adhesion molecule (L1CAM)-specific antibody comprising a heavy-chain variable region of SEQ ID NO. 1 and a light-chain variable region of SEQ ID NO. 5, a polynucleotide encoding the antibody, an expression vector comprising the polynucleotide, a transformant introduced with the vector, a pharmaceutical composition for preventing or treating cancer comprising the antibody, a method for treating cancer using the antibody, a composition for diagnosing cancer comprising the antibody, a kit for diagnosing cancer comprising the composition, a method for providing information for cancer diagnosis using the antibody, and an antibody-drug conjugate prepared by conjugating a drug to the antibody.

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