The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 03, 2017
Filed:
Jun. 17, 2008
Achilleas Gravanis, Heraklion, GR;
Theodora Calogeropoulou, Athens, GR;
Elias Castanas, Heraklion, GR;
Andreas Margioris, Heraklion, GR;
Ioannis Charalambopoulos, Heraklion, GR;
Nikolaos Avlonitis, Korydallos, GR;
Vassilios Minas, Rodos, GR;
Vasileia-ismini Alexaki, Heraklion, GR;
Christos Tsatsanis, Heraklion, GR;
Michael N. Alexis, Athens, GR;
Eumorphia Remboutsika, Vari, GR;
Varvara Vergou, Athens, GR;
Constantinos Neophytou, Nicosia, CY;
Achilleas Gravanis, Heraklion, GR;
Theodora Calogeropoulou, Athens, GR;
Elias Castanas, Heraklion, GR;
Andreas Margioris, Heraklion, GR;
Ioannis Charalambopoulos, Heraklion, GR;
Nikolaos Avlonitis, Korydallos, GR;
Vassilios Minas, Rodos, GR;
Vasileia-Ismini Alexaki, Heraklion, GR;
Christos Tsatsanis, Heraklion, GR;
Michael N. Alexis, Athens, GR;
Eumorphia Remboutsika, Vari, GR;
Varvara Vergou, Athens, GR;
Constantinos Neophytou, Nicosia, CY;
BIONATURE E. A. LTD., , CY;
Abstract
The present invention relates to novel neurosteroid derivatives with anti-apoptotic, neuroprotective and neurogenic properties that act on the nervous system as well as methods for making the same and their applications in the treatment and/or prevention or amelioration of neurodegenerative diseases related to neuronal apoptosis or neuronal injury, or conditions related to or resulting from apoptosis, including but not limited to Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis and amyotrophic lateral sclerosis (ALS), retinal degeneration and detachment, peripheral neuropathy caused by genetic abnormalities, diabetes, polio, herpes, AIDS and chemotherapy, brain trauma, or ischemia and stroke. The active compounds are represented by Formula (I): wherein R, R, R, R, R, R, R, A, B, X, Y and Z are defined in the description of the invention. The present invention also includes compositions which comprise one or more of the compounds of Formula (I).