The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 03, 2017

Filed:

Jan. 22, 2015
Applicant:

Abbvie Inc., North Chicago, IL (US);

Inventors:

Robert J. Altenbach, Chicago, IL (US);

Huaqing Liu, Buffalo Grove, IL (US);

Bruce Clapham, Lindenhurst, IL (US);

Ana L. Aguirre, Chicago, IL (US);

Marlon Cowart, Round Lake Beach, IL (US);

John R. Koenig, Chicago, IL (US);

Kathy Sarris, Mundelein, IL (US);

Marc J. Scanio, Lindenhurst, IL (US);

Kerren K. Swinger, Lexington, MA (US);

Anil Vasudevan, Union Grove, WI (US);

Clara I. Villamil, Glenview, IL (US);

Kevin R. Woller, Antioch, IL (US);

Assignee:

AbbVie Inc., North Chicago, IL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 407/12 (2006.01); C07D 491/048 (2006.01); C07D 491/20 (2006.01); C07D 519/00 (2006.01); C07D 307/83 (2006.01); C07D 405/12 (2006.01); C07D 491/107 (2006.01); C07D 493/10 (2006.01);
U.S. Cl.
CPC ...
C07D 519/00 (2013.01); C07D 307/83 (2013.01); C07D 405/12 (2013.01); C07D 407/12 (2013.01); C07D 491/048 (2013.01); C07D 491/107 (2013.01); C07D 491/20 (2013.01); C07D 493/10 (2013.01);
Abstract

Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R, Z, Z, and n are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by Tropomysin receptor kinases (Trk). Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.


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