The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 03, 2017
Filed:
Aug. 14, 2014
William Marsh Rice University, Houston, TX (US);
Bristol-myers Squibb Company, Princeton, NJ (US);
The Scripps Research Institute, La Jolla, CA (US);
Kyriacos C. Nicolaou, Houston, TX (US);
Min Lu, Houston, TX (US);
Debashis Mandal, Houston, TX (US);
Sanjeev Gangwar, Foster City, CA (US);
Naidu S. Chowdari, Dublin, CA (US);
Yam B. Poudel, San Mateo, CA (US);
WILLIAM MARSH RICE UNIVERSITY, Houston, TX (US);
THE SCRIPPS RESEARCH INSTITUTE, La Jolla, CA (US);
BRISTOL-MYERS SQUIBB COMPANY, Princeton, NJ (US);
Abstract
In one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates comprising the compounds of formulae (I) and (II).