The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 03, 2017

Filed:

Nov. 18, 2013
Applicant:

Takeda Pharmaceutical Company Limited, Osaka-shi, Osaka, JP;

Inventors:

Takahiro Sugimoto, Kanagawa, JP;

Minoru Nakamura, Kanagawa, JP;

Hiroki Sakamoto, Kanagawa, JP;

Shinkichi Suzuki, Kanagawa, JP;

Masami Yamada, Kanagawa, JP;

Makoto Kamata, Kanagawa, JP;

Takuto Kojima, Kanagawa, JP;

Ikuo Fujimori, Kanagawa, JP;

Kenichiro Shimokawa, Kanagawa, JP;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 221/02 (2006.01); A61K 31/44 (2006.01); C07D 487/04 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 401/06 (2006.01); C07D 403/10 (2006.01); C07D 403/14 (2006.01); C07D 405/12 (2006.01); C07D 409/14 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 453/02 (2006.01); C07D 471/04 (2006.01); C07D 471/14 (2006.01); C07D 209/46 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 209/46 (2013.01); C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 403/10 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 453/02 (2013.01); C07D 471/04 (2013.01); C07D 471/14 (2013.01); C07D 519/00 (2013.01);
Abstract

Provided is a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, and useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder and the like. The present invention relates to a compound represented by the formula wherein ring A is a 4- to 7-membered ring optionally having substituent(s); L is —O—, —S—, —SO— or —SO—; Ris a Calkyl group optionally having substituent(s) (provided that when L is —O—, Ris not a Calkyl group optionally substituted by halogen atom(s)), or a cyclic group optionally having substituent(s); Xis —CRa═ or —N═; Xis —CRb═ or —N═; Xis —CRc= or —N═; Ra, Rb and Rc are each a Calkyl group, Calkenyl group, Calkoxy group, Ccycloalkyl group, Ccycloalkoxy group or Caryl group, each of which optionally having substituent(s), H or halogen, or a salt thereof.


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