The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 03, 2017
Filed:
Nov. 22, 2013
Applicant:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Inventors:
Shawn P. Walsh, Bridgewater, NJ (US);
Brian Cato, Secaucus, NJ (US);
Jessica L. Frie, Harleysville, PA (US);
Dooseop Kim, Seoul, KP;
Alexander Pasternak, Princeton, NJ (US);
Zhi-Cai Shi, Monmouth Junction, NJ (US);
Assignee:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/10 (2006.01); C07D 405/14 (2006.01); A61K 45/06 (2006.01); A61K 31/401 (2006.01); A61K 31/404 (2006.01); A61K 31/41 (2006.01); A61K 31/4178 (2006.01); A61K 31/4184 (2006.01); A61K 31/4422 (2006.01); A61K 31/55 (2006.01); A61K 31/675 (2006.01); C07D 413/14 (2006.01); C07D 405/06 (2006.01); C07D 405/12 (2006.01); C07D 409/14 (2006.01); C07D 417/14 (2006.01); C07D 471/08 (2006.01); C07D 211/58 (2006.01); A61K 31/4353 (2006.01); A61K 31/4439 (2006.01); A61K 31/4468 (2006.01); A61K 31/4525 (2006.01); A61K 31/453 (2006.01); A61K 31/4535 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61K 31/4725 (2006.01); A61K 31/497 (2006.01); A61K 31/501 (2006.01);
U.S. Cl.
CPC ...
C07D 471/10 (2013.01); A61K 31/401 (2013.01); A61K 31/404 (2013.01); A61K 31/41 (2013.01); A61K 31/4178 (2013.01); A61K 31/4184 (2013.01); A61K 31/4353 (2013.01); A61K 31/4422 (2013.01); A61K 31/4439 (2013.01); A61K 31/4468 (2013.01); A61K 31/453 (2013.01); A61K 31/454 (2013.01); A61K 31/4525 (2013.01); A61K 31/4535 (2013.01); A61K 31/4545 (2013.01); A61K 31/4725 (2013.01); A61K 31/497 (2013.01); A61K 31/501 (2013.01); A61K 31/55 (2013.01); A61K 31/675 (2013.01); A61K 45/06 (2013.01); C07D 211/58 (2013.01); C07D 405/06 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/08 (2013.01);
Abstract
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.