The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 03, 2017

Filed:

Oct. 18, 2016
Applicants:

Pottayil Govindan Nair Sasikumar, Bangalore, IN;

Muralidhara Ramachandra, Bangalore, IN;

Seetharamaiah Setty Sudarshan Naremaddepalli, Bangalore, IN;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 285/12 (2006.01); C07D 271/10 (2006.01); A61K 31/433 (2006.01); A61K 45/06 (2006.01); A61K 31/4245 (2006.01);
U.S. Cl.
CPC ...
C07D 285/12 (2013.01); A61K 31/4245 (2013.01); A61K 31/433 (2013.01); A61K 45/06 (2013.01); C07D 271/10 (2013.01);
Abstract

The present invention relates to 1,3,4-oxadiazole and 1,3,4-thiadiazole compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signalling pathway. The invention also refers to derivatives of the therapeutic agents. The invention also encompasses the use of the said therapeutic agents and derivatives for treatment of disorders via immunopotentiation comprising inhibition of immunosuppressive signal induced due to PD-1, PD-L1, or PD-L2 and therapies using them.


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