The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 03, 2017
Filed:
Nov. 10, 2009
Joseph G. Sodroski, Medford, MA (US);
Navid Madani, Newton, MA (US);
Arne Schön, Baltimore, MD (US);
Judith M. Lalonde, Havertown, PA (US);
Joel R. Courter, Glen Mills, PA (US);
Takahiro Soeta, Ishikawa, JP;
Danny NG, Daly City, CA (US);
Ernesto Freire, Baltimore, MD (US);
Amos B. Smith, Iii, Merion, PA (US);
Amy M. Princiotto, Attleboro, MA (US);
Matthew Le-khac, Brooklyn, NY (US);
Wayne A. Hendrickson, New York, NY (US);
Joseph G. Sodroski, Medford, MA (US);
Navid Madani, Newton, MA (US);
Arne Schön, Baltimore, MD (US);
Judith M. LaLonde, Havertown, PA (US);
Joel R. Courter, Glen Mills, PA (US);
Takahiro Soeta, Ishikawa, JP;
Danny Ng, Daly City, CA (US);
Ernesto Freire, Baltimore, MD (US);
Amos B. Smith, III, Merion, PA (US);
Amy M. Princiotto, Attleboro, MA (US);
Matthew Le-Khac, Brooklyn, NY (US);
Wayne A. Hendrickson, New York, NY (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
The Johns Hopkins University, Baltimore, MD (US);
Bryn Mawr College, Bryn Mawr, PA (US);
The Trustees of Columbia University in the City of New York, New York, NY (US);
Abstract
The invention provides for compounds of formula I: wherein Z is absent or (CRR)W; each RA and RB is independently (i) H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, haloalkyl, each of which may be optionally substituted; (ii) OH, ORc, NH2, NHR, NRR, SH, S(O)R; or (iii) Rand Rtogether form C(O); W is absent, C(O), C(O)O, C(O)NRR, O, S(O), or NRR; Y is an optionally substituted heterocyclic, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted aryl, or NRR; wherein Rand Rare each independently H, alkyl or aryl; Xis selected from the group consisting of halogen, methyl, and hydroxyl; X2 is a halogen; each Ris independently alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl, each of which may be optionally substituted; m is O, 1, or 2; and n is 1, 2, 3, 4, 5, or 6; and pharmaceutically acceptable salts thereof.