The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 03, 2017
Filed:
Apr. 28, 2017
Daiichi Sankyo Company, Limited, Chuo-ku, Tokyo, JP;
Masashi Watanabe, Tokyo, JP;
Takahiro Okachi, Kanagawa, JP;
Michiaki Kawahara, Tokyo, JP;
Hiroshi Nagasawa, Kanagawa, JP;
Noritada Sato, Kanagawa, JP;
Takashi Takita, Kanagawa, JP;
Gen Hasegawa, Kanagawa, JP;
Daiichi Sankyo Company, Limited, Chuo-ku, JP;
Abstract
The present invention provides a production intermediate of an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, a method for producing the same, and a crystal thereof. A method for producing an atropisomer of a pyrrole derivative including a step of resolving a compound represented by the following general formula (I) [wherein Rrepresents a methyl group or a trifluoromethyl group, Rrepresents a hydrogen atom or a C1-C3 alkoxy group, and n represents an integer selected from 1 to 3] into its atropisomers, characterized by using an optically active amine having a cinchonine skeletal formula, and a crystal of (S)-1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide.