The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 03, 2017
Filed:
Apr. 02, 2014
Applicant:
Halozyme, Inc., San Diego, CA (US);
Inventors:
Gilbert Keller, Belmont, CA (US);
Gregory I. Frost, Palm Beach, FL (US);
Assignee:
Halozyme, Inc., San Diego, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/48 (2006.01); C12N 9/64 (2006.01);
U.S. Cl.
CPC ...
A61K 38/4873 (2013.01); A61K 38/482 (2013.01); A61K 38/488 (2013.01); A61K 38/4813 (2013.01); C12N 9/6472 (2013.01); C12N 9/6491 (2013.01); C12Y 304/22015 (2013.01); C12Y 304/24007 (2013.01);
Abstract
Methods and combinations are provided for controlling the duration of action, in vivo, of matrix-degrading enzymes. The methods and combinations permit temporary in-vivo activation of matrix-degrading enzymes upon administration to the extra cellular matrix (or 'ECM'). Matrix-degrading enzymes having a controlled duration of action can be used to treat ECM-mediated diseases or disorders characterized by increased deposition or accumulation of one or more ECM components.