The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 26, 2017

Filed:

Jul. 19, 2016
Applicant:

Massachusetts Institute of Technology, Cambridge, MA (US);

Inventors:

Jason Michael Tucker-Schwartz, Cambridge, MA (US);

Shivang Rajendra Dave, Boston, MA (US);

German Gonzalez Serrano, Alicante, ES;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 21/00 (2006.01); G01N 21/49 (2006.01); G01N 15/02 (2006.01); G01N 15/14 (2006.01); G01N 21/64 (2006.01); G01N 33/483 (2006.01); G02B 21/34 (2006.01); G02B 21/16 (2006.01); G02B 21/10 (2006.01); G01N 15/00 (2006.01); G01N 15/10 (2006.01);
U.S. Cl.
CPC ...
G01N 21/49 (2013.01); G01N 15/0211 (2013.01); G01N 15/1429 (2013.01); G01N 15/1434 (2013.01); G01N 15/1463 (2013.01); G01N 21/6458 (2013.01); G01N 21/6486 (2013.01); G01N 33/483 (2013.01); G02B 21/10 (2013.01); G02B 21/16 (2013.01); G02B 21/34 (2013.01); G01N 2015/008 (2013.01); G01N 2015/0073 (2013.01); G01N 2015/1006 (2013.01); G01N 2015/1081 (2013.01); G01N 2201/062 (2013.01); G01N 2201/12 (2013.01);
Abstract

System for scatter-based differentiation of cells. The system includes a planar substrate having cells disposed thereon for imaging and a microscope employing relatively low magnification detection optics providing a wide field of view focused on the cells on the substrate and defining a microscope optical axis. An illuminator delivers light to the ceils on the substrate focused to a spot larger than the field of view of the microscope, the illuminator having an illumination optical axis highly oblique to the microscope optical axis wherein scattered light is collected by the microscope. A detection system receives the scattered light from the microscope to provide a measure of signal intensity and a measure of size for each cell for discrimination of cell type.


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