The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 26, 2017

Filed:

Mar. 14, 2013
Applicants:

Children's Medical Center Corporation, Boston, MA (US);

President and Fellows of Harvard College, Cambridge, MA (US);

Joslin Diabetes Center Inc., Boston, MA (US);

Inventors:

Leonard I. Zon, Wellesley, MA (US);

Cong Xu, Boston, MA (US);

Amy J. Wagers, Cambridge, MA (US);

C. Ronald Kahn, Newton, MA (US);

Assignees:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/02 (2006.01); C12N 5/077 (2010.01); G01N 33/50 (2006.01); G01N 33/569 (2006.01); A61K 38/18 (2006.01); A61K 38/28 (2006.01); A61K 38/30 (2006.01); A61K 35/545 (2015.01);
U.S. Cl.
CPC ...
C12N 5/0658 (2013.01); A61K 35/545 (2013.01); A61K 38/1808 (2013.01); A61K 38/1825 (2013.01); A61K 38/1841 (2013.01); A61K 38/1858 (2013.01); A61K 38/28 (2013.01); A61K 38/30 (2013.01); G01N 33/5044 (2013.01); G01N 33/56983 (2013.01); C12N 2501/01 (2013.01); C12N 2501/115 (2013.01); C12N 2501/16 (2013.01); C12N 2501/999 (2013.01); C12N 2506/02 (2013.01); C12N 2506/45 (2013.01);
Abstract

Disclosed are methods of inducing differentiation of stem into myogenic cells without gene manipulation and for inducing proliferation of satellite cells. The cells can be used as a source of cells for transplantation in a subject in need thereof. Also disclosed is a screening assay for screening test compounds using blastomere cultures.


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