The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 26, 2017
Filed:
Dec. 16, 2014
Applicant:
Duke University, Durham, NC (US);
Inventors:
Ashutosh Chilkoti, Durham, NC (US);
Felipe Garcia Quiroz, Durham, NC (US);
Miriam Amiram, Chapel Hill, NC (US);
Assignee:
Duke University, Durham, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/00 (2006.01); A61K 9/51 (2006.01); A61K 47/42 (2017.01); B82Y 5/00 (2011.01); C07K 14/78 (2006.01); C07K 19/00 (2006.01); A61K 8/11 (2006.01); A61K 8/64 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/001 (2013.01); A61K 8/11 (2013.01); A61K 8/64 (2013.01); A61K 9/5123 (2013.01); A61K 9/5169 (2013.01); A61K 38/00 (2013.01); A61K 47/42 (2013.01); B82Y 5/00 (2013.01); C07K 14/78 (2013.01); C07K 19/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/21 (2013.01);
Abstract
The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be accompanied by aggregation. Polypeptides include a number of repeated motifs and may be elastomeric or non-elastomeric. The polypeptides may be used to deliver therapeutics to a biological site and to develop bioactive polypeptides that are environmentally responsive.