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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9771376 B1

PDFFull Text
Date of Patent:
Sep. 26, 2017

Filed:

Apr. 19, 2016

N-substituted benzamides and methods of use thereof

Applicants:

Genentech, Inc., South San Francisco, CA (US);

Xenon Pharmaceuticals Inc., Burnaby, CA;

Inventors:

Sultan Chowdhury, Burnaby, CA;

Christoph Martin Dehnhardt, Burnaby, CA;

Thilo Focken, Burnaby, CA;

Michael Edward Grimwood, Burnaby, CA;

Ivan William Hemeon, Burnaby, CA;

Qi Jia, Burnaby, CA;

Daniel F. Ortwine, South San Francisco, CA (US);

Brian Safina, South San Francisco, CA (US);

Shaoyi Sun, Burnaby, CA;

Daniel P. Sutherlin, South San Francisco, CA (US);

Alla Yurevna Zenova, Burnaby, CA;

Assignees:

GENENTECH, INC., South San Francisco, CA (US);

XENON PHARMACEUTICALS INC., Burnaby, BC, CA;

Attorney:

Viksnins Harris Padys Malen LLP

Primary Examiner:

Noble Jarrell

Assistant Examiner:

Daniel Carcanague

Int. Cl.
CPC ...
C07D 257/04 (2006.01); C07D 471/08 (2006.01); C07D 207/46 (2006.01); C07D 213/64 (2006.01); C07C 311/51 (2006.01); C07D 233/84 (2006.01); C07D 205/04 (2006.01); C07D 491/107 (2006.01); C07D 403/12 (2006.01); C07D 213/82 (2006.01); C07D 311/58 (2006.01); C07D 265/30 (2006.01); C07C 307/06 (2006.01); C07D 295/26 (2006.01); C07D 207/48 (2006.01); C07D 311/70 (2006.01); C07D 413/12 (2006.01); C07D 451/02 (2006.01); C07D 307/12 (2006.01); C07D 309/08 (2006.01); C07D 311/72 (2006.01); C07D 405/12 (2006.01); C07D 211/22 (2006.01); C07D 295/192 (2006.01); C07D 211/96 (2006.01); C07D 307/18 (2006.01); A61K 31/18 (2006.01); A61K 31/397 (2006.01); A61K 31/40 (2006.01); A61K 31/41 (2006.01); A61K 31/4164 (2006.01); A61K 31/44 (2006.01); A61K 31/5375 (2006.01); C07D 209/52 (2006.01);
U.S. Cl.
CPC ...
C07D 491/107 (2013.01); A61K 31/18 (2013.01); A61K 31/397 (2013.01); A61K 31/40 (2013.01); A61K 31/41 (2013.01); A61K 31/4164 (2013.01); A61K 31/44 (2013.01); A61K 31/5375 (2013.01); C07C 307/06 (2013.01); C07C 311/51 (2013.01); C07D 205/04 (2013.01); C07D 207/46 (2013.01); C07D 207/48 (2013.01); C07D 209/52 (2013.01); C07D 211/22 (2013.01); C07D 211/96 (2013.01); C07D 213/64 (2013.01); C07D 213/82 (2013.01); C07D 233/84 (2013.01); C07D 257/04 (2013.01); C07D 265/30 (2013.01); C07D 295/192 (2013.01); C07D 295/26 (2013.01); C07D 307/12 (2013.01); C07D 307/18 (2013.01); C07D 309/08 (2013.01); C07D 311/58 (2013.01); C07D 311/70 (2013.01); C07D 311/72 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 413/12 (2013.01); C07D 451/02 (2013.01); C07D 471/08 (2013.01); C07B 2200/05 (2013.01); C07C 2601/02 (2017.05); C07C 2601/04 (2017.05); C07C 2601/08 (2017.05); C07C 2601/14 (2017.05); C07C 2601/16 (2017.05); C07C 2601/18 (2017.05); C07C 2602/10 (2017.05); C07C 2602/18 (2017.05); C07C 2602/20 (2017.05); C07C 2602/42 (2017.05); C07C 2602/44 (2017.05); C07C 2602/50 (2017.05); C07C 2603/66 (2017.05); C07C 2603/68 (2017.05); C07C 2603/74 (2017.05);
Abstract

The invention provides novel compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables R, subscript n, ring A, X, L, subscript m, X, B, R, R, R, R, Rand Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

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