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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9771375 B1

PDFFull Text
Date of Patent:
Sep. 26, 2017

Filed:

Jul. 23, 2014

Indazole compounds useful as ketohexokinase inhibitors

Applicant:

Janssen Pharmaceutica NV, Beerse, BE;

Inventors:

Xuqing Zhang, Audubon, PA (US);

Marta C Abad, Downingtown, PA (US);

Alan C. Gibbs, Wyndmoor, PA (US);

Gee-Hong Kuo, Scotch Plains, NJ (US);

Fengbin Song, Princeton, NJ (US);

Zhihua Sui, Norristown, PA (US);

Lawrence C. Kuo, Gwynedd Valley, PA (US);

Assignee:

Janssen Pharmaceutica NV, Beerse, BE;

Attorney:

Baker & Hostetler LLP

Primary Examiner:

Susanna Moore

Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61P 3/10 (2006.01); A61P 3/04 (2006.01); A61P 3/06 (2006.01); C07D 471/04 (2006.01); C07D 491/08 (2006.01); C07D 231/56 (2006.01); C07D 401/04 (2006.01); C07D 401/10 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/10 (2006.01); C07D 403/12 (2006.01); C07D 487/10 (2006.01); A61K 31/437 (2006.01);
U.S. Cl.
CPC ...
C07D 491/08 (2013.01); C07D 231/56 (2013.01); C07D 401/04 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/10 (2013.01); C07D 403/12 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 487/10 (2013.01);
Abstract

The present invention is directed to substituted indazole compounds, pharmaceutical compositions of these compounds and methods of use thereof. The compounds of the present invention are ketohexokinase (KHK) inhibitors, useful for treating or ameliorating a KHK mediated metabolic disorders and/or diseases such as obesity, Type II diabetes mellitus and Metabolic Syndrome X. In some embodiments, the substituted indazole compounds are of formula I, wherein R-R, Q, X, Y, Z, a, and b are defined herein.

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