The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 26, 2017
Filed:
Feb. 12, 2016
Applicant:
Merck & Cie, Schaffhausen, CH;
Inventors:
Simon Mensah Ametamey, Zurich, CH;
Rudolf Moser, Schaffhausen, CH;
Tobias Ludwig Ross, Zurich, CH;
Viola Groehn, Dachsen, CH;
Assignee:
MERCK & CIE, Schaffhausen, CH;
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/62 (2006.01); C07D 475/08 (2006.01); A61K 51/04 (2006.01); C07D 475/04 (2006.01); G01N 33/574 (2006.01); G01N 33/60 (2006.01); G01N 33/82 (2006.01);
U.S. Cl.
CPC ...
C07D 475/08 (2013.01); A61K 51/0459 (2013.01); A61K 51/0497 (2013.01); C07D 475/04 (2013.01); G01N 33/57492 (2013.01); G01N 33/60 (2013.01); G01N 33/82 (2013.01); C07B 2200/05 (2013.01); G01N 2333/705 (2013.01);
Abstract
The present invention is directed towards newF-folate radiopharmaceuticals, wherein the fluorine-18 is covalently linked to the aminobenzoyl moiety, which connects the condensed pyrimidine heterocycle to the amino acid portion within folate structures, as well as their precursors and their non-radioactive references, a method of their preparation, as well as their use in diagnosis of a cell or population of cells expressing a folate-receptor and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.