The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 26, 2017
Filed:
Oct. 10, 2016
Applicant:
Theravance Biopharma R&d Ip, Llc, South San Francisco, CA (US);
Inventors:
Melissa Fleury, Brisbane, CA (US);
Roland Gendron, San Francisco, CA (US);
Adam D. Hughes, Half Moon Bay, CA (US);
Jane Schmidt, San Francisco, CA (US);
Assignee:
Theravance Biopharma R&D IP, LLC, South San Francisco, CA (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/42 (2006.01); C07D 261/18 (2006.01); A61K 45/06 (2006.01); A61K 47/48 (2006.01); A61K 31/437 (2006.01); A61K 31/4355 (2006.01); A01N 47/16 (2006.01); C09K 15/30 (2006.01); C07D 213/81 (2006.01); C07D 237/04 (2006.01); A61K 31/4196 (2006.01);
U.S. Cl.
CPC ...
C07D 261/18 (2013.01); A61K 31/42 (2013.01); A61K 45/06 (2013.01); A01N 47/16 (2013.01); A61K 31/4196 (2013.01); A61K 31/437 (2013.01); A61K 31/4355 (2013.01); A61K 47/48738 (2013.01); C07D 213/81 (2013.01); C07D 237/04 (2013.01); C09K 15/30 (2013.01);
Abstract
In one aspect, the invention relates to compounds having the formula: where R, R, R, X, R, R, and Rare as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.