The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 26, 2017

Filed:

Mar. 27, 2013
Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Pei-yu E. Chiou, Los Angeles, CA (US);

Kuo-wei Huang, Hillsboro, OR (US);

Yu-jui Fan, Taipei, TW;

Yu-chun Kung, Los Angeles, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 27/453 (2006.01); B03C 5/00 (2006.01); G01N 27/447 (2006.01); B03C 5/02 (2006.01); G01N 15/06 (2006.01); B01L 3/00 (2006.01); G01N 15/00 (2006.01); G01N 15/10 (2006.01);
U.S. Cl.
CPC ...
B03C 5/005 (2013.01); B01L 3/502761 (2013.01); B03C 5/026 (2013.01); G01N 15/0656 (2013.01); G01N 27/44778 (2013.01); B01L 2200/0652 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0864 (2013.01); B01L 2300/0867 (2013.01); B01L 2400/0424 (2013.01); B01L 2400/0655 (2013.01); B03C 2201/26 (2013.01); G01N 2015/0065 (2013.01); G01N 2015/1081 (2013.01);
Abstract

A 3-dimensional PDMS cell sorter having multiple passages in a PDMS layer that follow the same path in a DEP separation region and that are in fluid communication with each other within that region. The passages may differ in width transverse to the flow direction within the passages. Flat plates may sandwich the PDMS layer; each plate may have a planar electrode used to generate a DEP field within a sample fluid flowed within the passages. The DEP field may concentrate target cells or particulates within one of the passages within the DEP separation region. The passages may diverge after the DEP-separation region, leaving one passage with a high concentration of target cells or particulates. Techniques for manufacturing such structures, as well as other micro-fluidic structures, are also provided.


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