The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 26, 2017

Filed:

Jan. 17, 2014
Applicant:

Exxpharma Therapeutics Llc, Somerville, NJ (US);

Inventors:

Isaac Ghebre-Sellassie, Morris Plains, NJ (US);

Hibreniguss Terefe, Piscataway, NJ (US);

Assignee:

ExxPharma Therapeutics LLC, Somerville, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/26 (2006.01); A61K 47/48 (2006.01); A61K 31/138 (2006.01); A61K 31/485 (2006.01); A61K 9/20 (2006.01); A61K 31/137 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48184 (2013.01); A61K 9/2009 (2013.01); A61K 9/2027 (2013.01); A61K 9/2054 (2013.01); A61K 9/2077 (2013.01); A61K 31/137 (2013.01); A61K 31/138 (2013.01); A61K 31/485 (2013.01);
Abstract

The invention provides a tamper-resistant dosage form including a therapeutic agent-substrate complex embedded in a thermo-formable matrix; such that the complex includes at least one therapeutic agent bound to at least one substrate to form the therapeutic agent-substrate complex. The at least one substrate is being selected from the group consisting of a polyelectrolyte, an organic counter-ion, a pharmacologically inert organic component of a prodrug, an inclusion compound and an inorganic adsorbent; and the thermo-formable matrix includes one or more thermoplastic polymers and optionally at least one pharmaceutical additive.


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