The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 26, 2017
Filed:
Sep. 16, 2013
Applicant:
Tel Hashomer Medical Research Infrastructure and Services Ltd., Ramat-Gan, IL;
Inventors:
Benjamin Dekel, Tel-Aviv, IL;
Orit Harari-Steinberg, RaAnana, IL;
Assignee:
Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramat-Gan, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); A61K 35/22 (2015.01); C12N 5/071 (2010.01); C12N 5/074 (2010.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
A61K 35/22 (2013.01); C12N 5/0686 (2013.01); C12N 5/0687 (2013.01); C12N 5/0696 (2013.01); C12N 15/85 (2013.01); C12N 2500/90 (2013.01); C12N 2501/06 (2013.01); C12N 2501/065 (2013.01); C12N 2501/415 (2013.01); C12N 2506/25 (2013.01);
Abstract
A method of reprogramming a differentiated renal cell towards a progenitor phenotype is disclosed. The method comprises up-regulating in the differentiated renal cell an expression of at least one pluripotency associated gene and/or at least one renal stem cell associated gene, thereby reprogramming the differentiated renal cell towards a progenitor phenotype. Cell populations generated thereby and uses thereof are also disclosed.