The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 26, 2017
Filed:
Jun. 07, 2013
The Johns Hopkins University, Baltimore, MD (US);
Aduro Biotech, Inc., Berkeley, CA (US);
Thomas W. Dubensky, Jr., Piedmont, CA (US);
Meredith Lai Ling Leong, Oakland, CA (US);
Drew M. Pardoll, Brookeville, MD (US);
Young Jun Kim, Ellicott City, MD (US);
ADURO BIOTECH, INC., Berkeley, CA (US);
THE JOHNS HOPKINS UNIVERSITY, Baltimore, MD (US);
Abstract
The present invention provides a combination therapy which relies on a small molecule immune stimulator—cyclic-di-nucleotide (CDN)—that activates DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes) formulated with allogeneic human tumor cell lines engineered to secrete high amounts of GM-CSF. This combination therapy can provide an ideal synergy of multiple tumor associated antigens, DC recruitment and proliferation, coupled with a potent DC activation stimulus.