The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 26, 2017

Filed:

Oct. 25, 2016
Applicant:

Takeda Pharmaceutical Company Limited, San Diego, CA (US);

Inventors:

Stephen Hitchcock, San Diego, CA (US);

Holger Monenschein, San Diego, CA (US);

Holly Reichard, San Diego, CA (US);

Huikai Sun, San Diego, CA (US);

Shota Kikuchi, San Diego, CA (US);

Todd Macklin, San Diego, CA (US);

Maria Hopkins, San Diego, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/53 (2006.01); A61K 31/5377 (2006.01); C07D 241/44 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 405/12 (2006.01); A61K 31/197 (2006.01); A61K 31/498 (2006.01); A61K 31/4985 (2006.01); A61K 31/5025 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/5377 (2013.01); A61K 31/197 (2013.01); A61K 31/498 (2013.01); A61K 31/4985 (2013.01); A61K 31/5025 (2013.01); A61K 45/06 (2013.01); C07D 241/44 (2013.01); C07D 405/12 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01);
Abstract

The present invention provides compounds of Formula (I): that are GPR6 modulators and are therefore useful for the treatment of diseases treatable by modulation of GPR6, in particular treating Parkinson disease, levodopa induced dyskinesias, Huntington's disease, other dyskinesias, akinesias, and motor disorders involving dysfunction of the striatum, schizophrenia and drug addiction. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.


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