The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2017
Filed:
Aug. 02, 2012
Clara Montagut Viladot, Barcelona, ES;
Joan Albanell Mestres, Barcelona, ES;
Ana Rovira Guerin, Barcelona, ES;
Beatriz Bellosillo Paricio, Barcelona, ES;
Alba Dalmases Massegú, Barcelona, ES;
Clara Montagut Viladot, Barcelona, ES;
Joan Albanell Mestres, Barcelona, ES;
Ana Rovira Guerin, Barcelona, ES;
Beatriz Bellosillo Paricio, Barcelona, ES;
Alba Dalmases Massegú, Barcelona, ES;
FUNDACIO INSTITUT MAR D'INVESTIGACIONS MEDIQUES (IMIM), Barcelona, ES;
Abstract
The invention relates to a new identified mutation in the epidermal growth factor receptor gene, leading to an amino acidic change which highly correlates with the resistance to a therapy regimen comprising cetuximab and the sensitivity to a therapy regimen comprising panitumumab. The invention includes peptide sequences, primers and probes to detect such a mutation, as well as kits for predicting the response of a subject to a therapy regime comprising cetuximab and/or panitumumab. In particular, the invention is useful in the therapy regimen applicable to metastasic colorectal cancer and to head and neck cancer.