The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2017
Filed:
Mar. 03, 2016
Guangdong Pharmaceutical University, Guangzhou, CN;
Wenjie Mei, Guangzhou, CN;
Guangdong Pharmaceutical University, Guangzhou, CN;
Abstract
The present invention discloses an application of ruthenium complexes as nucleic acid vectors into target cell nucleuses. Experimental data shows that ruthenium (II) complexes may be effectively combined with nucleic acid sequence and may effectively change morphologies of long nucleic acid sequences to effectively deliver the nucleic acids into viable cells via transmembrane transport located within cell nucleuses, thus greatly improving transport efficiency of the nucleic acids. Based on this property, nucleic acid sequences can be conveniently transported into cells for gene therapy or fluorescent tracking or the like. The method for preparing a ruthenium coordination complex-nucleic acid complex in accordance with the present invention may provide a more effective and stable ruthenium coordination complex-nucleic acid complex.