The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2017
Filed:
Nov. 24, 2015
Applicant:
John Chaput, Phoenix, AZ (US);
Inventor:
John Chaput, Phoenix, AZ (US);
Assignee:
Arizona Board of Regents on Behalf of Arizona State University, Scottsdale, AZ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/00 (2006.01); C12N 15/11 (2006.01); C07H 1/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/111 (2013.01); C07H 21/00 (2013.01); C07H 1/00 (2013.01); C12N 2310/32 (2013.01); C12N 2310/323 (2013.01); C12N 2320/51 (2013.01);
Abstract
The present invention provides stable, nuclease-resistant TNA and TNA-DNA oligonucleotides, wherein the oligonucleotides are completely resistant to enzymatic degradation for at least 24-72 hours. Methods of synthesis and use in diagnostic and therapeutic applications are also provided. Specifically, in one embodiment, we describe the chemical and biological stability of TNA and mixed-backbone (mosaic) TNA-DNA oligonucleotides under a variety of conditions and sequence contexts.