The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2017
Filed:
Sep. 11, 2014
Applicant:
Geron Corporation, Menlo Park, CA (US);
Inventors:
Sergei M. Gryaznov, San Mateo, CA (US);
Ronald G. Schultz, Urbana, MO (US);
Assignee:
Geron Corporation, Menlo Park, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07H 21/04 (2006.01); C07H 19/04 (2006.01); C12N 15/11 (2006.01); C07H 21/00 (2006.01); C07H 19/06 (2006.01); C07H 19/10 (2006.01); C07H 19/16 (2006.01); C07H 19/20 (2006.01); C12N 15/113 (2010.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
C07H 21/00 (2013.01); C07H 19/04 (2013.01); C07H 19/06 (2013.01); C07H 19/10 (2013.01); C07H 19/16 (2013.01); C07H 19/20 (2013.01); C12N 15/113 (2013.01); C12N 15/1137 (2013.01); C12Q 1/6816 (2013.01); C12Q 1/6876 (2013.01); C12N 2310/11 (2013.01); C12Q 1/6813 (2013.01); C12Q 2600/158 (2013.01);
Abstract
Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2'-arabino-fluoronucleoside and an internucleoside 3′-NH—P(—O)(OR)—O-5′ linkage, where R is a positively charged counter ion or hydrogen, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive phosphoramidate 2′-arabino-fluorooligonucleotides have a high RNA binding affinity to complementary nucleic acids and are base and acid stable.