The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 19, 2017

Filed:

Feb. 06, 2017
Applicant:

Allergan, Inc., Irvine, CA (US);

Inventors:

David W. Old, Irvine, CA (US);

Vinh X. Ngo, Huntington Baech, CA (US);

Mark Holoboski, Irvine, CA (US);

Mari Posner, Laguna Niguel, CA (US);

Assignee:

ALLERGAN, INC., Irvine, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/381 (2006.01); A61K 31/38 (2006.01); A61K 31/41 (2006.01); C07D 333/10 (2006.01); C07D 409/08 (2006.01); C07D 333/40 (2006.01); C07D 277/56 (2006.01);
U.S. Cl.
CPC ...
C07D 409/08 (2013.01); A61K 31/38 (2013.01); A61K 31/381 (2013.01); A61K 31/41 (2013.01); C07D 277/56 (2013.01); C07D 333/10 (2013.01); C07D 333/40 (2013.01);
Abstract

Disclosed herein are compounds having formula (I) wherein a dashed line represents the presence or adsence of a bond; Y is an organic acid functional group, or an amide or ester thereof; or Y is hydroxymethyl or an ester thereof; or Y is a tetrazolyl functional group; A is —(CH)—, cis —CHCH═CH—(CH)—, or —CHC═C—(CH)—, wherein 1 or 2 carbon atoms may be replaced by S or O; or A is —(CH)—Ar—(CH)—, wherein Ar is interarylene or heterointerarylene, the sum of m and o is 1, 2, 3, or 4, and wherein 1 —CH— may be replaced by S or O, and 1 —CH—CH— may be replaced by —CH═CH— or —C≡C—; Uand Uare independently selected from —H, ═O, —OH, —F, —Cl, and —CN; and B is aryl or heteroaryl, for use as acular hypotensive agent.


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