The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2017
Filed:
Dec. 22, 2016
Applicant:
The Scripps Research Institute, La Jolla, CA (US);
Inventors:
Vladimir Kravchenko, San Diego, CA (US);
Richard J. Ulevitch, La Jolla, CA (US);
Kim D. Janda, La Jolla, CA (US);
Assignee:
The Scripps Research Institute, La Jolla, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 307/04 (2006.01); C07D 307/34 (2006.01); C07D 405/12 (2006.01); A61K 38/17 (2006.01); A61K 31/336 (2006.01);
U.S. Cl.
CPC ...
C07D 405/12 (2013.01); A61K 31/336 (2013.01); A61K 38/1761 (2013.01);
Abstract
The invention is directed to methods of inducing apoptosis, arresting cell cycle, or inhibiting cellular proliferation, or any combination thereof, in a tumor cell, by administration of an effective amount of an N-acyl homoserine lactone analog (AHL), optionally in conjunction with a tumor modulating agent such tumor necrosis factor (TNF) related apoptosis inducing ligand (TRAIL) to the patient. Novel bioactive analogs of an N-acyl homoserine lactone are also provided.