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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9765018 B1

PDFFull Text
Date of Patent:
Sep. 19, 2017

Filed:

Jul. 01, 2014

Ido inhibitors

Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Jay A. Markwalder, Lahaska, PA (US);

Steven P. Seitz, Swarthmore, PA (US);

James Aaron Balog, Lambertville, NJ (US);

Audris Huang, New Hope, PA (US);

Sunil Kumar Mandal, Bangalore, IN;

David K. Williams, Delran, NJ (US);

Amy C. Hart, Ewing, NJ (US);

Jennifer Inghrim, Plainsboro, NJ (US);

Assignees:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Syngene International Limited, Bangalore, Karnataka, IN;

Bristol-Myers Squibb Company, Princeton, NJ (US);

Attorneys:

Serena Farquharson-Torres

Elliott Korsen

Primary Examiner:

Zinna Northington Davis

Int. Cl.
CPC ...
C07C 275/42 (2006.01); C07C 311/51 (2006.01); C07D 213/75 (2006.01); C07D 257/04 (2006.01); C07D 401/04 (2006.01); A61K 31/18 (2006.01); A61K 31/41 (2006.01); A61K 31/44 (2006.01); C07D 213/79 (2006.01); C07D 307/86 (2006.01); A61K 31/196 (2006.01); A61K 31/277 (2006.01); A61K 31/343 (2006.01); A61K 31/4418 (2006.01); A61K 31/444 (2006.01); A61K 45/06 (2006.01); C07C 311/09 (2006.01); C07D 307/79 (2006.01);
U.S. Cl.
CPC ...
C07C 275/42 (2013.01); A61K 31/18 (2013.01); A61K 31/196 (2013.01); A61K 31/277 (2013.01); A61K 31/343 (2013.01); A61K 31/41 (2013.01); A61K 31/444 (2013.01); A61K 31/4418 (2013.01); A61K 45/06 (2013.01); C07C 311/09 (2013.01); C07C 311/51 (2013.01); C07D 213/75 (2013.01); C07D 213/79 (2013.01); C07D 257/04 (2013.01); C07D 307/79 (2013.01); C07D 307/86 (2013.01); C07D 401/04 (2013.01); C07C 2101/02 (2013.01); C07C 2101/14 (2013.01); C07C 2102/08 (2013.01); C07C 2102/10 (2013.01);
Abstract

There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

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