IDiyas

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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9765016 B1

PDFFull Text
Date of Patent:
Sep. 19, 2017

Filed:

Jan. 29, 2014

S1p modulating agents

Applicant:

Biogen MA Inc., Cambridge, MA (US);

Inventors:

Kevin Guckian, Northborough, MA (US);

Gnanasambandam Kumaravel, Lexington, MA (US);

Xiaogao Liu, Dover, MA (US);

Bin Ma, Arlington, MA (US);

Hairuo Peng, Needham, MA (US);

Assignee:

BIOGEN MA INC., Cambridge, MA (US);

Attorneys:

McCarter & English, LLP

Steven G. Davis

Xin Zhang

Primary Examiner:

D M Seaman

Int. Cl.
CPC ...
C07C 229/14 (2006.01); C07C 229/48 (2006.01); C07C 229/50 (2006.01); C07D 205/04 (2006.01); C07D 207/08 (2006.01); C07D 207/16 (2006.01); C07D 211/34 (2006.01); C07D 211/62 (2006.01); A61K 31/196 (2006.01); A61K 31/197 (2006.01); A61K 31/198 (2006.01); A61K 31/397 (2006.01); A61K 31/40 (2006.01); A61K 31/445 (2006.01); A61K 31/695 (2006.01); A61K 45/06 (2006.01); C07F 7/08 (2006.01);
U.S. Cl.
CPC ...
C07C 229/14 (2013.01); A61K 31/196 (2013.01); A61K 31/197 (2013.01); A61K 31/198 (2013.01); A61K 31/397 (2013.01); A61K 31/40 (2013.01); A61K 31/445 (2013.01); A61K 31/695 (2013.01); A61K 45/06 (2013.01); C07C 229/48 (2013.01); C07C 229/50 (2013.01); C07D 205/04 (2013.01); C07D 207/08 (2013.01); C07D 207/16 (2013.01); C07D 211/34 (2013.01); C07D 211/62 (2013.01); C07F 7/0812 (2013.01); C07C 2601/04 (2017.05); C07C 2601/08 (2017.05); C07C 2601/14 (2017.05); C07C 2602/26 (2017.05); C07C 2602/44 (2017.05);
Abstract

Compounds of formula (I) can modulate the activity of one or more S 1P receptors. Sphingosine 1-phosphate (S IP) is a lysophospholipid mediator that evokes a variety of cellular responses by stimulation of five members of the endothelial cell differentiation gene (EDG) receptor family, namely S1P1, S1P2, S1P3, S1P4, and S1P5 (formerly EDG1, EDG5, EDG3, EDG6 and EDG8). The EDG receptors are G-protein coupled receptors (GPCRs) and on stimulation propagate second messenger signals via activation of heterotrimeric G-protein alpha (Ga.) subunits and beta-gamma (G( )y) dimers.

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