The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2017
Filed:
Apr. 07, 2015
Ucl Business Plc, London, GB;
Thrombosis Research Institute, Chelsea, GB;
St. Jude Children's Research Hospital, Memphis, TN (US);
Amit Nathwani, London, GB;
Natalie Ward, London, GB;
Adrian Thrasher, London, GB;
Edward Tuddenham, London, GB;
John Mcvey, London, GB;
John Gray, Memphis, TN (US);
Andrew Davidoff, Memphis, TN (US);
UCL BUSINESS PLC, London, GB;
THROMBOSIS RESEARCH INSTITUTE, London, GB;
ST. JUDE CHILDREN'S RESEARCH HOSPITAL, Memphis, TN (US);
Abstract
An optimized coding sequence of human blood clotting factor eight (VIII) and a promoter may be used in vectors, such as rAAV, for introduction of factor VIII, and/or other blood clotting factors and transgenes. Exemplary of these factors and transgenes are alpha-1-antitrypsin, as well as those involved in the coagulation cascade, hepatocye biology, lysosomal storage, urea cycle disorders, and lipid storage diseases. Cells, vectors, proteins, and glycoproteins produced by cells transformed by the vectors and sequence, may be used in treatment.