The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2017
Filed:
Apr. 07, 2014
Applicant:
Cedars-sinai Medical Center, Los Angeles, CA (US);
Inventors:
Keith L. Black, Los Angeles, CA (US);
Dwain Morris-Irvin, Los Angeles, CA (US);
Moshe Arditi, Encino, CA (US);
Assignee:
CEDARS-SINAI MEDICAL CENTER, Los Angeles, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/15 (2015.01); A61K 39/00 (2006.01); A61K 38/16 (2006.01); A61K 45/06 (2006.01); C12N 5/0784 (2010.01);
U.S. Cl.
CPC ...
A61K 39/0011 (2013.01); A61K 35/15 (2013.01); A61K 38/164 (2013.01); A61K 45/06 (2013.01); C12N 5/0639 (2013.01); A61K 2039/5154 (2013.01); A61K 2039/55561 (2013.01); A61K 2039/55572 (2013.01);
Abstract
Compositions comprising dendritic cells pulsed with tumor lysate and at least one toll-like receptor (TLR) ligand which may be used for eliciting a specific immune response in a mammal in need thereof for treating diseases including a tumor are disclosed. Also disclose are methods of activating dendritic cells, comprising providing at least one toll-like receptor (TLR) ligand; and pulsing a dendritic cell with the at least one TLR ligand. A method further comprises pulsing the dendritic cell with a tumor lysate.