The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9764005 B1

PDF
Full Text
Expired
Date of Patent:
Sep. 19, 2017

Filed:

Aug. 26, 2015
Applicant:

Academia Sinica, Taipei, TW;

Inventors:

Shu-Mei Liang, Bethesda, MD (US);

Ching-Feng Chiu, Tainan, TW;

Shao-Wen Hung, Pingtung County, TW;

Jei-Ming Peng, Taoyuan, TW;

Chi-Ming Liang, Bethesda, MD (US);

Assignee:

Academia Sinica, Taipei, TW;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/38 (2006.01); A61K 38/16 (2006.01); A61K 47/48 (2006.01); C07K 14/765 (2006.01); A61K 45/06 (2006.01); A61N 5/10 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/385 (2013.01); A61K 38/162 (2013.01); A61K 38/38 (2013.01); A61K 45/06 (2013.01); A61K 47/48284 (2013.01); A61N 5/10 (2013.01); C07K 14/765 (2013.01); C12N 7/00 (2013.01); C12N 2770/32133 (2013.01);
Abstract

Methods of using fibrillar proteins are provided for suppressing cancer metastasis. Cancer metastasis is the most common cause of treatment failure and death in cancer patients. Tumor cell invasion and/or migration can be significantly inhibited after fibrillar proteins (rVP1, F-HSA, and F-BSA) treatment in vitro. In addition, rVP1 can significantly suppress murine and human breast cancer metastasis and human prostate and ovarian cancer metastasis in vivo while F-HSA can significantly suppress murine breast cancer metastasis.


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